If you're like me, you hate drinking. I refuse to do it in raids and I'm constantly running out in the world and fighting things with 3% HP so that a random scrub rogue with a name like Darkshasta or Mugger can come along and one-shot me with a 200 damage Assassinate.
So to combat this I have been using what might be the ultimate solo PvE spec: 32 BD / 18 Sin / 16 RS this build relies primarily on Rift Scavenger and Combat Culmination which restore your energy and health if you have combo points left on the target when it dies. Combine this with the massive CP generation from having mobs attack you as a BD, and you can tear through packs of mobs that would leave any other spec dead, and come out with 100% HP.
cast Precision Strike
cast Quick Strike
cast Keen Strike
cast Flash of Steel
cast Blade Tempo
cast Double Coup
cast Poison Malice
Press repeatedly for victory. Keep False Blade and Dauntless Strike up, but make sure to have combo points on the mobs as they die for health/energy boosts.
It's sick for closing Rifts solo, farming, doing dailies or whatever. I don't recommend it if you expect PvP though. You'll get trashed by anyone except champ or beast warriors (and maybe bad assassins). Props to Archaego for originally coming up with the idea.
I'd also recommend this spec for anyone thinking of leveling a rogue. The key idea is to get 3/3 Rift Scavenger in RS, then put the rest of your points in Bladedancer up to 32, then build up Assassin or RS as you wish.
Leave your water in the bank. You won't need it.